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Abstract. Barbosa IG, Vale TC, de Macedo DL, Gomez RS, Teixeira AL

Barbosa IG, Vale TC, de Macedo DL, Gomez RS, Teixeira AL. Neurosyphilis presenting as mania. Bipolar Disord 2012: 14: 309-312. © 2012 The Authors. Journal compilation © 2012 John Wiley & Sons A/S. Objective:  General paresis of the insane is a late and severe form of neurosyphilis characterized by nonspecific neuropsychiatric symptoms. There are a limited number of case reports of mood disorders presenting in neurosyphilis, with depressive illness being the most common. Methods:  We performed a literature review of case reports of secondary bipolar disorder induced by syphilitic infection. Results:  Herein reported is a case of a 53-year-old woman who initially presented with symptoms of mania and depression, mimicking bipolar disorder, but was subsequently diagnosed with general paresis of the insane. Conclusion:  The present case report emphasizes that if a substantial delay occurs in syphilis diagnosis and management, the patient may have a very poor prognosis.

J Neurol Sci. 2012 Jun 15;317(1-2):35-9. Epub 2012 Apr 4.

Ischemic stroke as a primary symptom of neurosyphilis among HIV-negative emergency patients.

Liu LL, Zheng WH, Tong ML, Liu GL, Zhang HL, Fu ZG, Lin LR, Yang TC.

Source

Center of Clinical Laboratory, Zhongshan Hospital, Medical College of Xiamen University, Xiamen 361004, China; Xiamen Zhongshan Hospital, Fujian Medical University, Xiamen 361004, China.

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