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Family Studies
The great majority of family studies have shown increased risks for schizophrenia, schizoaffective disorder, and schizotypal personality disorder in the relatives of probands with schizophrenia.7 Family studies of bipolar disorder, on the other hand, have shown increased familial risks of bipolar disorder, schizoaffective disorder, and unipolar depression.8 In contrast, the majority of studies have failed to find a familial relationship between schizophrenia and bipolar disorder.9–14 Thus, the weight of evidence has traditionally been interpreted to support the view that schizophrenia and bipolar disorder largely breed true. This conclusion has been challenged by family studies suggesting shared familial risk15,16 and by the observation that families exist in which some relatives have schizophrenia, some have bipolar disorder, and some have both psychosis and mood disorder.17 Moreover, the position of schizoaffective disorder has appeared somewhat anomalous in the context of a strict dichotomous view. Thus, schizoaffective disorder occurs at similarly increased rates both in families of probands with schizophrenia18 and in those of probands with bipolar disorder.19 Moreover, both schizophrenia and bipolar disorder have been shown to occur at increased rates in families of probands with schizoaffective disorder.19 This is supported by one of the largest family studies to date, which used the Swedish inpatient case register and obtained data on over 13 000 cases of schizophrenia and 5000 cases of bipolar disorder.20 The cross-disorder incidence ratios were robustly increased in siblings and half-siblings for both schizophrenia and bipolar disorder. Дата добавления: 2015-08-26 | Просмотры: 406 | Нарушение авторских прав |