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Theme #5. Genomics, proteomics and metabolonomics

2. The aim: Formation at students of modern ideas concerning the structurally functional organization of living organisms’ genomes, and also genomics and its directions.

3. The tasks:

3.1. The structure of eukaryote genome. Mobile genome elements.

3.2. Genomics and its directions.

3.3. Proteomics - a new direction in biology and medicine of the XXI century.

3.4. Metabolonomics and new medicine development.

3.5. Bioinformatics and its prospects.

4. Performance form: glossary compiling.

1. Allele - _________________________________________________

2. Amplification - __________________________________________

3. Bioinformatics -__________________________________________

4. Databases - _____________________________________________

5. Genome library - ________________________________________

6. Biochips - ______________________________________________

7. Vector - ________________________________________________

8. Genetic code - ___________________________________________

9. Genetic engineering - _____________________________________

10. Gene - ________________________________________________

11. Genome - _______________________________________________

12. Genomics - _____________________________________________

13. Genetic map - ___________________________________________

14. DNA polymerases - _______________________________________

15. Gene therapy - ___________________________________________

16. Cloning - _______________________________________________

17. Complementary DNA - ______________________________________

18. Genetic code - ___________________________________________

19. Codon (triplet) - __________________________________________

20. Mapping - ______________________________________________

21. Clone - _________________________________________________

22. Locus - _________________________________________________

23. Metabolomics - __________________________________________

24. Metabolonics - __________________________________________

25. Metabolome - ______________________________________________

26. Nanotechnology - ________________________________________

27. The project “Human genome” - ______________________________

28. Proteome - ______________________________________________

29. Proteomics - _____________________________________________

30. Primer - ________________________________________________

31. Pseudogenes - ___________________________________________

32. Polymorphism - __________________________________________

33. Polymerase chain reaction - ________________________________

34. Plasmid - _______________________________________________

35. Restrictase - _____________________________________________

36. Recombinant DNA - _______________________________________

37. Revertase - _____________________________________________

38. PHomics - ______________________________________________

39. Satellite DNA - ___________________________________________

40. Selective medium - _______________________________________

41. Sequencing - ____________________________________________

42. Transformation - _________________________________________

43. Transposon - _____________________________________________

44. Tandem array - ___________________________________________

45. Transcriptomics - __________________________________________

46. Transcriptome - ___________________________________________

47. Toxicogenomics - _________________________________________

48. Comparative genomics - ____________________________________

49. Functional genomics - _____________________________________

50. Evolutionary genomics - ___________________________________

5. Performance criteria:

а) selection and studying of basic literary sources on the researched problem;

b) written design in a form of extracts and abstracts;

c) information processing and systematization;

d) abstract compiling and design.

Requirements to glossary design:

а) the volume of glossary should include not less than 50 terms;

b) a glossary should be compiled with brief and concrete explanations;

c) correct presentation of the bibliography list.

6. Deadline: before the midterm control on the chapter “Molecular cytobiology”.

7. Criteria of assessment: - 100 points at maximum that corresponds to 100%

8. Bibliography:

8.1. Арчаков А. И. Что за геномикой? – Протеомика. //Вопр. мед.химии, 2000. Т. 46, № 4. С. 335–343.

8.2. Арчаков А.И. Биоинформатика, геномика и протеомика - науки о жизни XXI столетия / Вопросы медицинской химии, № 1, 2000. URL: http://medi.ru/pbmc/8800101.htm (дата обращения 12.10.2009)

8.3. Замятнин А.А. Блистающий мир белков и пептидов. //Биология. 2002. № 25–26. P. 8–13.

8.4. Ясный И.Е., Цыбина Т.А., Шамшурин Д.В., Колосов П.М.

8.5. Интернет сайты:

Структурная геномика и медицина // Молекулярная медицина. - 2009. - № 6. - С. 15-20.

http://www.bioinformatix.ru/proteomika/proteomika.-lider-nauki-xxi-veka.html

http://www.bioinformatix.ru/genomika/

http://www.bioinformatix.ru/metabolomika/

http://www.bioinformatix.ru/transkriptomika/

http://www.bioinformatix.ru/bioinformatika/

9. Check:

1. Modern genome concepts.

2. Differences between procaryote and eukaryote genomes.

3. Significance of genomics in medicine.

4. Prospects of proteomics studying.

5. Application of information on human metabolism for biologically active additives and medicine creation.

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