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Figure 3

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  1. Figure 1
  2. Figure 1.18
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  5. Figure 5
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Inverse relationship between the number of synovial forkhead box P3 (FoxP3)–positive regulatory T cells and interleukin-17 (IL-17)–positive, CD4+ T cells. A, Representative dot plots of paired samples of peripheral blood mononuclear cells (PBMCs) and synovial fluid mononuclear cells (SFMCs) from a patient with juvenile idiopathic arthritis (JIA) and of samples of PBMCs from a healthy control subject. Cells were stained for surface expression of CD3, CD4, and CD25 and then for intracellular expression of FoxP3 and were analyzed by flow cytometry, gated on live lymphocytes and CD3+,CD4+ cells. Numbers in each compartment are the percentage of cells. B, Numbers of FoxP3+ cells as a percentage of CD4+ T cells in PBMCs and SFMCs from patients with persistent (n = 8) and extended (n = 5) oligoarticular JIA (O-JIA) and in PBMCs from 6 healthy controls. Bars show the median. C, Comparison of the numbers of IL-17+ and FoxP3+ cells as percentages of CD4+ T cells in SFMCs from 15 JIA patients. Linear regression was performed on log-transformed data.

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