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SQUAMOUS CELL CARCINOMA OF THE CERVIX UTERI GRADE W

Mrs. M. W. received the Oxidation Reagent in the same dose as the J. K. colon case. It was also a most malignant invasive growth.

She was examined by three physicians, led by Dr. Loeffler, on January 12, 1940. He reported: “Her cancerous condition would probably, if untreated, end her life within a year. Because of the fixation of the uterus and the involvement of the adnexia, it is my opinion that it was not a surgical case, as surgery would have to be too extensive. It was too late for that sort of thing.” It had already entered the cachexia stages, Dr. Loeffler stated, “She had lost 30 pounds in six weeks, complaining of general weakness, and had a rather poor color at the time.” Examination showed it had broken through the pelvis and entered the abdomen.

Dr. Loeffler gave the Reagent on March 20, 1940, December 30, 1940, and in October 1941. His examination made a year and a half later in the summer of 1942, recorded: “She had gained weight; she had gained color and improved in appearance. The mass in the abdomen had subsided to the extent that I could no longer palpate it. The appearance of the cervix by examination with the speculum appeared normal,” Before Treatment was given, she was taken to the Medford Hospital where a biopsy was taken. The diagnosis by Dr. Green, the Hospital pathologist, was “squamous cell cancer of the cervix uteri.” But because of its highly malignant characteristics, it was sent to Dr. Hunter, the Professor of Pathology of the University of Oregon. He gave the following diagnosis: “I see a decidedly invasive and anaplastic carcinoma, which occupies well over half of the tissues.” It was graded four, which would be the highest degree of malignancy that is recognized. The specimen was submitted later to Dr. Weller, the Professor of Pathology of the University of Michigan. He reported as follows: “Prepared section # 2751, our 3823-LAW. Tissue from cervix: Medullary squamous cell carcinoma of poorly differentiated type. Histological Grade IV.” December 7, 1944.

There was considerable interest in this case and to make sure of her status she was given a laparotomy on June 1944, by the surgeon, Dr. Haines. He found her pelvis normal with a small fibroid attached to the body of the uterus. The cervix was found to be perfectly normal and was left in its place. The body of the uterus, with the fibroid, was removed and given a careful serial sectioning for a careful search for malignant cells. Dr. Innskeep, the pathologist, reported there were no cancer cells found in the body of the uterus or in the fibroid. Thus, she was found cancer free by the most rigid test, in her fifth year after being treated. Ten years after Treatment, Dr. Loeffler was called to see her just before she died. He attempted to do an autopsy, but found the lower bowel and surrounding area to be a necrotic mass that was too foul to be of use for a specimen. The odor would not permit it. He did not know the uterus had been removed and sectioned and found cancer free, but he signed the death certificate “death from cancer.” His report to Dr. Koch was, however, that he did not determine what the necrotic affair was and could not say it was not a gangrenous diverticulosis. The case teaches that cancer can be reversed to normal in about the same time it took to develop and a malignant or equally serious pathology can start again, in the same position many years later, when the hygienic conditions are very unfavorable, as they were in this case.

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