АкушерствоАнатомияАнестезиологияВакцинопрофилактикаВалеологияВетеринарияГигиенаЗаболеванияИммунологияКардиологияНеврологияНефрологияОнкологияОториноларингологияОфтальмологияПаразитологияПедиатрияПервая помощьПсихиатрияПульмонологияРеанимацияРевматологияСтоматологияТерапияТоксикологияТравматологияУрологияФармакологияФармацевтикаФизиотерапияФтизиатрияХирургияЭндокринологияЭпидемиология

DIABETES

It will be seen that this disease as currently met in the great majority of cases is an intoxication that blocks islet cell function. The energy of ATP does not enter the fibrillae that synthesize insulin in the affected cell. If the situa­tion lasts long enough, some of the cells die off and are only slowly replaced after the toxin is removed. The case of Mrs. M. J. E. P. will illustrate. On the other hand in fairly early cases, as Mr. L. S. of only one year’s duration, even with a very high blood sugar 320 mgm.%, there may be a hyperplasia of islet cells, which are also paralyzed by integration with the poison so when this is renewed, the effect of the hyperplasia is seen in that the blood sugar stays at a very low normal level or less, 75 mgm.%

Mr. L S., age 53, had a rich venereal past, malaria at 21, and operated for varices in 1941. He complained of vertigo, edema of the legs, grade 2 small varicosities, aorta palpaple, fundus oculi showed veins with second grade mani­festation (Wagner), blood pressure 240/130, pulse 96, glycemia 112 mgm.%. Clortiazamide reduced the blood pressure to 210/110 with vertigo. On January 19, 1960, there was dyspnoea, and blood pressure 200/110; on February 14, blood pressure 220/120, pulse 84; on May 16, vertigo, tachycardia, dyspnoea and after lying down, blood pressure 250/130, pulse 90. On August 18 epistaxis, blood pressure 260/120, dyspnoea, constrictive feeling in neck, blood sugar 320 mgm.%, urea normal. Thus, there was a steady rapid deterioration during the pre-treatment control period. One-tenth of a microgram of the serial system of Carbonyl groups was given on September 24, 1960. He had a reaction on the following day. The edema and constrictive feeling in the neck disappeared quickly and in three weeks he felt very well, weight 82 kilos, blood pressure 170/100, blood sugar 75 mgm.%. He has remained in good health. One sees that the diabetes was but one feature of a multiple symptom poisoning. Before the Reagent was given, all insulin and other drugs were stopped. He was taken off of animal proteins and placed on an unrestricted cereal, vegetable, and fruit diet, with sugar, honey, and molasses. This diet is our usual procedure followed in diabetes. He has remained well with high efficiency islet function as the low blood sugar persistently shows. (9)

The reaction in this case was severe with chills, fever, and general muscular pains, especially in the legs. When one compares this reaction with the mild one of the following case, one sees that the etiological factors were different and caused different general effects, though they both affected the islet cells in the same way — that is, blocked their function.

The structures of the etiological toxin then were different, but they still had the one feature in common; namely, the ability to integrate with the islet cell’s functional mechanisms and this com­mon feature we identify as the activated position alpha to a double bond, which provided for the integration and also invited the oxidative separation. Evidently there are a number of toxins that have different general effects, but are able to attack and integrate with the islet cells by the same mechanism—a mechanism that invites separation from the host cell by using the same Reagent, in exactly the same way.