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The nerve cell gives the best chance to observe viral integration and its separation. The restored function being the criterion, for anterior horn cells do not reproduce
Two states of viral integration with the host cell’s functional mechanism are known, the lytic in which the host cell is quickly and completely destroyed and its energy and substance are used up for viral vegetation. This is the only type encountered in rabies and the full destruction takes about four days. In dog distemper, the other type of integration where the virus lives in symbiosis with the host cell is that usually encountered, but the rapid lytic type may intervene at any time. Eventually the symbiosis yields to a lytic destruction with possible fatality. Here energy production and acceptance is completely blocked and the host cell and virus appear to be dead. The host cell withers and the axis cylinder of the nerve fiber appears to be lost. There is no function and the dependent tissue atrophies and the growth of the affected limb are hindered more or less. The invalidism caused is equal to that of the lytic type. Still the virus can be removed and the host cell will recuperate so that the dependent tissues and growth of the limb will be restored, even twenty years after the infection took place. This is the best type to demonstrate our Thesis. During the acute phase, it is not always possible to differentiate between the two types, except that the rapid spread of paralysis and the violence of the toxic attack, speaks for the lytic type. Its reversal is also the quickest when treated early.
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