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Circulatory failure

Primary toxicogenic collapse is characterized by a sudden and rapid development of circulatory failure in which compensatory mechanisms have no time to turn on and comes a sudden death. Such situation is possible in a closed space with high concentration of vapour- or gaseous toxic substances, with atmosphere without oxygen owing to putrefaction, combustion or sprouted grain, as well as in intoxication with superdoses of highly effective poisons. A primary toxicogenic collapse makes up 1-5% of all cases with lethal poisonings. Treatment lies in carrying out a cardiopulmonary resuscitation.

Exotoxic shock is the result of hypovolemia (in poisoning with corroding liquids, dichlorethane), a drop of vascular tone (barbiturates, OPC) or cardiotoxic effect (veratrin, barium chloride, echinopanax tincture, strophantin, OPC). It is diagnosed in 65-70% of fatal outcomes in poisonings. In intoxication with corrosive poisons a removal of pain syndrome with anesthetizing agents is of great significance.

Secondary somatogenic collapse is a manifestation of nonspecific toxic myocardial dystrophy under conditions of insufficient function of the liver, kidneys or respiration. It is the cause of death in 30-35% of fatal poisonings. Its therapy is the same as in the treatment of cardiovascular insufficiency.

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