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Theme: Transcription

2. Object: Form students’ knowledge of molecular mechanisms of realization of hereditary information on the level of transcription in prokaryotes.

3. Educational Tasks:

- to form students’ knowledge of the essence of transcription;

- to study molecular mechanisms of different stages of transcription;

- to study and understand peculiarities of transcription in prokaryotic organisms;

- to study the role of transcription in providing functioning of living organisms;

- to study and understand the significance of impairment of transcription in occurrence of pathologic processes (diseases);

- to know terms

4. Principal Questions of the Theme:

4.1. Transcription, definition, characteristics

4.2. Matrix principle of synthesis of i-RNA, difference of transcription from replication

4.3. Mechanisms of transcription of prokaryotic genes:

1) initiation

2) elongation

3) termination

5. Methods of Teaching: interrogation aimed at clarification of students’ understanding of the essence, object, and objectives of the lesson; ability to briefly, clearly, logically recount and ability of draw the learnt material in the form of schemes, diagrams, drawings; testing with subsequent discussion of errors; work in group: explanation and demonstration of problem solution, filling-in tables.

6. Literature:

Basic:

6.1. Genetics. Under redaction of Ivanov V.I.M., 2006, pp.201-210

6.2. Ginter Y.K. Medical Genetics. M.,2003, p.35-46

6.3. Muminov T.A., Kuandykov Y.U. Fundamentals of Molecular Biology (Course of Lectures). Almaty, 2007, pp. 42-64

6.4. Mushkambrov N.N., Kusnetsov S.L. Molecular Biology. M., 2003, pp. 85-148

6.5. Yarygin

6.6. Medical Biology and Genetics. Study guide under redaction of Prof. Kuandykov Y.U. Almaty, 2004, pp. 29-41

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