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Theme #8. Genetics of human sex

2. The aim: to study chromosomal and molecular-genetic bases of primary and secondary determination of human sex.

3. The tasks:

3.1. Types of chromosomal sex determination.

3.2. The role of Y chromosome and autosomal genes in primary sex determination.

3.3. Secondary sex determination.

3.4. Sex dependent and sex limited characters.

3.5. Gynandromorphs, intersexes, hermaphrodites and other sexual deviations, medical significance.

4. Performance form: abstract work.

5. Performance criteria:

а) studying and selection of recent literary sources;

b) information processing and systematization;

c) plan designing;

d) bibliography compiling;

e) abstract and/or project work making up.

The structure of abstract work:

1) the title page (made up in due form);

2) the table of contents (consecutive statement with indication of the main sections page numbers);

3) introduction (substantiation of the researched problem, its importance and urgency; determination of the aims and tasks of work);

4) the main part (each section should reveal evidentially a particular problem or one of its aspects, be logic continuation of the previous material; tables, schemes, diagrams, figures can be presented in this section or they can be executed as annex to abstract work);

5) conclusion (the results are summed up, the deductions are formulated and recommendations are suggested);

6) the list of bibliography (made up in due form).

Requirements to abstract work design:

а) the volume of abstract work should not exceed 10-15 printing pages (annexes are not included into a paper volume);

b) a text of abstract work should be carefully edited and grammatically verified;

c) references should be presented in numbers, corresponding to the number in the list of bibliography;

d) the list of bibliography should be at the end of a text according to order of appearance.

6. Deadline: before the midterm control on the chapter “Fundamentals of general genetics”.

7. Criteria of assessment: - 100 points at maximum that corresponds to 100%

8. Bibliography:

8.1. Бочков Н.П. Клиническая генетика. М., 2004.

8.2. Генетика. Под ред. Иванова В.И. М., 2006.

8.3. Гинтер Е.К. Медицинская генетика. М., 2003.

8.4. Жимулев И.Ф. Общая и молекулярная генетика. Новосибирск, 2003.

8.5. Тейлор Д., Грин Н., Стаут У. Биология. М., 2002.

9. Check:

9.1. List the main types of sex determination.

9.2. What does the Y-chromosome role in sex determination consist in?

9.3. What is the role of autosomal genes in sex determination?

9.4. What factors influence the secondary sex determination?

9.5. What pathological conditions are formed at disturbance of sex determination?

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