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Theme: Regulation of Gene Expression

2. Object: Form students’ knowledge ofthe essence of gene expression, molecular mechanisms of gene activity regulation in prokaryotes.

3. Educational Tasks:

- to form students’ knowledge and understanding of the essence of gene expression;

- to study molecular-genetic mechanisms of gene activity regulation;

- to study peculiarities of regulation of prokaryotic genes.

4. Principal Questions of the Theme:

4.1. Gene activity regulation, concept, essence, significance in the viability of organisms (cells).

4.2. Operon model of gene activity regulationin prokaryotes

4.3. Types of gene activity regulation (negative, positive, inducible, repressible)

5. Methods of Teaching: interrogation aimed at clarification of students’ understanding of the essence, object, and objectives of the lesson; ability to briefly, clearly, logically recount and ability of draw the learnt material in the form of schemes, diagrams, drawings; testing with subsequent discussion of errors; work in group: explanation and demonstration of problem solution, filling-in schemes.

6. Literature:

Basic:

6.1. Ginter Y.K. Medical Genetics. M., 2003, p.28-50

6.2. Zhimulyov I.F. General and Molecular Genetics. Novosibirsk. 2003, pp. 107-196

6.3. Muminov T.A., Kuandykov Y.U. Fundamentals of Molecular Biology (Course of Lectures). Almaty, 2007, pp. 83-97

6.4. Mushkambrov N.N., Kusnetsov S.L. Molecular Biology. M., 2003, pp. 85-213

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