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Title: Apoptosis

2. Aims: To generate in students the knowledge and understanding the essence and value apoptosis, its role in insuring normal vital functions and development of pathological processes

3. Learning objectives:

- research on the causes and mechanisms of apoptosis.

- study of genetic, biochemical and morphological changes in cells to apoptosis.

- study of the causes and mechanisms of violations of apoptosis and its importance in the genesis and evolution of human pathologies.

4. Methods of study: combined method of training (interview, filling out tables, the job skills.)

5. Key questions the theme:

5.1. Apoptosis, definition.

5.2. Causes of apoptosis.

5.3. Stages of development of apoptosis.

5.4. Genetic control of apoptosis.

5.5. The medical significance of apoptosis.

6. Handout: test questions.

7. References:

The main:

7.1. Biology. Edited by VN Yarygin. M: 2001, Part 1, pp.347-351.

7.2. Genetics. Under Ivanov VI editor M:,2006, pp.557-568.

7.3. Kuandykova E.W, Muminov T.A. Fundamentals of Molecular Biology A.,2007,pp.132-141.

7.4.Mushkambarov N. Kuznecov S.L. "Molecular Biology" M: 2003. pp.443-501

7.5 Fuller, DM, Dennis Shilds.Molekulyarnaya cell biology.2006,pp134-137.

Additional:

7.1.Zhymulev I.F. Basis and Molecular genetics. 2006 pp.387-389.

7.2. Pehove A.P. Biology and general genetics. Moscow,2006, pp.640.

7.3.Genomica – Medicine. Edited byIvanova V.I.M., 2006, pp.392.

7.4. Kazymbet P.K. Myroedova E.P. Biology. Parts I,II. Astana, 2006,2007.

7.5. Konichev A.S. Molecular biology.M.,2005, p397.

8. Control:

8.1.. Rating of competences knowledge

8.1.1. Quiz on topics.

8.1.2.Tests. 3variants (each variant -10questions).

8.1.3. Filling out tables:escribe the types of apoptosis

2) Sign and explain stages of apoptosis in reducend figure:

3) Complete the missing links in the scheme appoptosis:

Injury(stress) Ligand Killer (Fas-L, TNF-α,)

Permeability of the mitochondrial membrane Activation of the receptor of death(FasKiller/ DRS5)

Capsize?

AIF, Cytochrom C Capsize?

Capsize?

Effectors capsize?

Key substrates

Apoptosis

8.1.4.Fill the table, “the difference morphological features of apoptosis and necrosis”

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