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Theme: Heredity. Types of inheritance. Monogenic traits linked inheritance

2. Purpose:

- Create the students' knowledge of the monogenic linked inheritance of normal

and pathological features of autosomal and X-and Y sex chromosomes;

- To develop the motivation of the need to study the linked inheritance of genes for

understanding the genetic mechanisms of hereditary diseases;

- To develop communication skills in the analysis of linked inheritance of monogenic human disease with autosomal and X-and Y sex chromosomes;

- Develop practical competence by applying knowledge of the mechanisms linked inheritance of normal and pathological features in human and model solutions and situational problems in genetics.

3. Learning objectives:

- Explain the nature of genetic terms: linked inheritance, linkage group, autosomal linkage group, linkage group with the sexual X-and Y-chromosomes,

- To reveal the genetic mechanisms of the full clutch, clutch, and violations of the basic provisions of the chromosome theory of heredity,

- To reveal the genetic mechanisms linked inheritance of normal and pathological signs of human

- Explain the need for knowledge of the types and mechanisms linked inheritance of genes in the diagnosis of hereditary diseases

- To reveal the genetic basis of making a genetic map of chromosome with the full clutch.

4. Key questions the theme:

4.1. The laws of inheritance established T.Morganom. Linked inheritance and its genetic basis.

4.2. Linkage group. Autosomal linkage groups and gonosomnye man.

4.3. Violations of the clutch and its genetic basis.

4.4. The main provisions of the chromosome theory of heredity.

4.5. Preparation of the genetic maps of chromosomes.

5. Teaching methods: oral questioning aimed at clarifying the understanding of the nature of student goals and objectives of the training, skills, short, clear, logically presented and the ability to depict the digested material in the form of charts, graphs, drawings, testing and subsequent analysis of errors in the work group: an explanation and demonstration solving problems, filling schemes.

5.1.Reshenie problems (Medical Biology and Genetics. Under. Ed. Kuandykova EW tasks on page 98-101, № 1-3, 9, 15).

5.2. Fill in the table "during gamete formation of linkage and clutch abuse."

The formation of gametes in linkage and clutch abuse

5.3. To make a genetic map: the distance between genes A and C is 12 map units, and the frequency of crossing over between genes A and B are equal to 4 percent of crossing over. Determine the distance between genes A, B, C, and make a map.

6. Literature:

The main:

6.1. Genetics. Under the editorship of Ivanov V. I. M, 2006, page 116-125.

6.2. Zhimulev I.F. General and molecular genetics. Novosibirsk, 2006, page 35-39,55-57.

6.3. Medical biology and genetics. The manual for students under the editorship of prof. Kuandykov E.U. Almaty, 2004, page 98-101.

6.4. Kuandykov E.U. Bases of the general and medical genetics (course of lectures). Almaty, 2007, page 81-98.

The additional:

6.5. Alikhanyan S. I., Akifyev A.P., Chernin L.S. General genetics of M, 1 volume, 1985, page 53-56.

6.6. Biology. Under the editorship of Yarygin V. N. M., book 1, 81-98.

6.7. Dorian Dzh. Pritchard, Bruce R. Korf. Evident medical genetics. The translation from English under edition Akkad. N.P.Bochkov's Russian Academy of Medical Science. - M: GEOTAR-media, 2009, page 42-60.

6.8. Hare of River of, Butvilovsky Century Э., etc. General and medical genetics. R - on - Don., 2002, page 76-80, 84-87.

6.9. Questions and tasks in the general biology and the general and medical genetics (with explanations). Under the editorship of the prof. Itkes A.V. M, 2004, page 68-83.

6.10. To Inga-Vechtomov S.G. Genetics with selection bases. M, 1989, page 23-54.

6.11. Medical genetics: studies. grant / Robert L.Nyyussbaum, Roderich of R, Macque-Innes, Huntington F.Willard: the lane with English. A.Sh.Latypov; under the editorship of N. P. Bochkov. - M: GEOTAR-media, 2010, page 203-205

7. Control:

7.1. Assessment of cognitive competences (knowledge):

7.1.1. Quizzes on topics.

7.1.2. Test Control - 4 options for the 10 questions.

7.2. Assessment of competence skills

7.2.1. Show, identify and characterize the allelic genes, homozygous, heterozygous and hemizygous.

7.2.2. Show monohybrid scheme, and dihibrid - polyhybrid crossing, determine the types of gametes with independent inheritance, genotypes, and paint phenotypes of F1.

7.2.3. Solution of standard and situational tasks on a grant: Medical biology and genetics. The manual for students under the editorship of prof. Kuandykov E.U. Almaty, 2004, page 98-102.

7.3. Assessment of skills of self-improvement:

7.3.1. Solution of standard and situational tasks on a grant: Medical biology and genetics. The manual for students under the editorship of prof. Kuandykov E.U. Almaty, 2004, page 98-102.

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