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Theme: DNA reparation

2. Purpose: to create at students of knowledge of molecular bases and mechanisms of restoration of violations of structure and DNA function.

3. Problems of training:

- to study types of damages of a molecule of DNA and mechanisms of their emergence,

- to study types and mechanisms of restoration of normal structure and DNA function,

- to study types and levels of protective anti-mutational mechanisms of an organism,

- to study a role of violations of processes of a reparation of DNA in emergence of hereditary diseases.

4. Main questions of a subject:

4.1. Anti-mutational barriers.

4.2. Reparation, types of a reparation and their mechanisms:

- photoreaktivisation;

- excisional repair;

- postreplikative repair;

- Miss - match repair;

- SOS- repair.

4.3. Biological and medical value of a reparation of DNA.

5. Training methods: the combined method of training (conversation, filling of tables, the solution of situational tasks)

6. Literature:

The main:

6.1. Genetics. Under the editorship of Ivanov V. I. M, 2006, page 164-181.

6.2. Muminov T.A., Kuandykov E.U. Bases of molecular biology (course of lectures). Almaty, 2007, page 156-157.

6.3. Mushkambarov N. N., Kuznetsov S. L. Molecular biology. M., 2003, page 78-82.

6.4. Shchipkov V.P., Krivosheina G. N. General and medical genetics. M, 2003, page 132-133.

The additional:

6.1. Gaynutdinov I.K., Ruban E.D. Medical genetics. Rostov-on-Don, 2007, page 170-173.

6.2. Tinmen V.D.Reparation of DNA and its biological value. L., 1979, page 285-293.

6.3. R.G.Obshchaya's hare and medical genetics. Rostov - on Don, 2002, page 137-143.

6.4. Spivak I.M. Hereditary diseases with primary and secondary defects of a reparation of DNA.//Cytology, 1999, т.41, page 338-379.

7. Control:

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