Lessons namber 3

Alpha

Generate students' current knowledge about the causes and molecular mechanisms of neoplastic cell transformation.

3.Learning objectives:

-to study the role by environmental (carcinogens) factors in the development of tumors --malignant.

-to study the classification of carcinogens

-to study the phase and molecular mechanisms of neoplastic cell transformation

1. Alpha

-to study the properties of malignant tumor cells

-to study the causes and mechanisms of transformation of proto-ontogenesis in ontogenesis

-to study the role of viruses in the oncogenesis

-to study the characteristics and functions antionkogens

-to study the importance of molecular genetic mechanisms of neoplastic transformation to diagnose, treat and prevent cancer.

4.Type of course: a conversation on the subjects fill the table, the job skills.

5.Key questions the theme:

5.1.Carcinogenic factors, classification, and their role in causing malignant transformation of cells

5.2. Proto-oncogenes and oncogenes, the concept, role in the origin and development of malignant transformation of cells

5.3. Oncoviruses, and their role in causing malignant transformation

5.4. Malignant tumors, stage of development properties

5.5. Antionkogens, the mechanisms of antitumor protection

5.6. The value of genetics in modern oncology.

6. Handout: test questions.

7. References:

The main:

7.1. Genetics. Under Ivanov VI editor M:,2006,p.557-568

7.2. Ginter EK "Medical Genetics" M: 2003.

7.3. IF Zhimulev "General and Molecular Genetics", Novosibirsk, 2007, pp400-411.

7.4. Kuandykov EW Fundamentals of general and medical genetics. Lectures, Almaty/2010, pp.59-62

7.5.Kuandykov E.U. Muminov T.A. Fundamentals of general and medical genetics. Lecture course, Almaty,2007 p. 201-216.

7.6. Mushkambarov N. "Molecular Biology" M: 2003. pp.501-520

8. Control:

8.1. Rating of competences knowledge

8.1..1. Quiz on topics.

8.1.2.Tests. 3variants (each variant -10questions).

8.1.3. Diagram of the effects of DNA damage cells carcinogens:

Carcinogen Modification of DNA Mutation

Reparation Apoptosis Transformation

???

8.1.4. Draw and explain the stages of cell transformation.

8.1.5. Fill in the table: Oncogenes and tumor suppressor genes

8.1.6. List the properties of malignant cells and to characterize tumor its features

8.1.7. Show and explain the mechanisms of transformation of proto-oncogene to ontogeny