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A. Evaluation of competence – knowledge

i. Interrogation on questions of the theme

7.1.7 Test control – 2 variants, 10 questions each

7.1.8 Filling in the table Individual Sensitivity of the Human Organism to Action of Medicines in Case of Genetic Impairments.

7.1.9 Filling in the table Response of the Organism for Medicinal Preparations

7.1.10 Solution of situation problems:

Match ferment impairments related to the following clinic situations:

a) Occurrence of hemolytic anemia after intake of Primaquine;

b) Long-term respiration arrest after intake of Ditilin;

c) A patient with lung tuberculosis has toxic reactions from use of Isoniazid

d) About 40% of Europeans do not fill bitter taste of phenylthiocarbamide

1 – anomalousacetyltransferase

2 – catalase deficit

3 – deficit of glucose-6-phasphatedehydrogenase

4 – anomalous pseudo cholinesterase

5 –tyrosinase deficit

7.1.11 Acatalasemia was discovered by otolaryngologist Takagara by accident during treatment with hydrogen peroxide of mucous membranes of the nasopharynx and mouth of a Japanese girl. During irrigation of the mucous membraneswith hydrogen peroxide, the blood turned brown. Later it was established that in case of acatalasemia ferment catalase is absent in blood of patients. Explain, why treatment of the wound with hydrogen peroxide is not efficient, i.e. action of the preparation is not seen, and what genotype the girl has.

7.1.12 In surgery for muscle relaxation, preparation Ditilin is used. Normally it arrests respiration (apnoea) for 2-3 minutes. In some patients after injection of Ditilin apnoea lasts for 1 hour and more. Such patients can be saved only with artificial lung ventilation for this time. Explain, deficit of what ferment and what type of inheritance of sensitivity to Ditilin cause such atypical reaction.

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