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Theme #1. Telomers. Telomerase activity

2. The aim: to study the mechanisms of restoration (prereplication) of the terminal sites of daughter chain of DNA.

3. The tasks:

3.1. Telomers and telomerase and their influence on cellular aging.

3.2. Telomerase expression in normal cells of a human.

3.3. Telomerase activity and length of telomers in tumor cells of a human.

3.4. Cancer diagnostics, telomerase activity and malignancy.

4. Performance form: presentation.

5. Performance criteria:

а) studying and selection of recent literary sources;

b) information processing and systematization;

c) plan designing;

d) bibliography compiling;

e) abstract and/or project work making up.

The structure of abstract work:

1) the title page (made up in due form);

2) the table of contents (consecutive statement with indication of the main sections page numbers);

3) introduction (substantiation of the researched problem, its importance and urgency; determination of the aims and tasks of work);

4) the main part (each section should reveal evidentially a particular problem or one of its aspects, be logic continuation of the previous material; tables, schemes, diagrams, figures can be presented in this section or they can be executed as annex to abstract work);

5) conclusion (the results are summed up, the deductions are formulated and recommendations are suggested);

6) the list of bibliography (made up in due form).

Requirements to presentation making up:

а) a presentation should be made on the basis of “Microsoft Power Point” program;

b) the number of slides should be no more than 10-15; slides shouldn't be loaded by a text material;

c) a presentation should be available to perception;

d) the list of bibliography should be presented on the last slide.

6. Deadline: before the midterm control on the chapter “Theory of molecular biology”.

7. Criteria of assessment: - 100 points at maximum that corresponds to 100%

8. Bibliography:

8.1. Биохимия, № 62, 1997.

8.2. Военно-медицинский журнал, № 11, 2000.

8.3. Жимулев И.Ф. Общая и молекулярная генетика. Новосибирск, 2006.

8.4. Мушкамбаров Н.Н., Кузнецов С.Л. Молекулярная биология. М., 2003.

8.5.Российский онкологический журнал, № 2, 2003.

8.6.Соросовский образовательный журнал, № 12, 1998.

9. Check:

9.1. Telomer and telomerase structural and functional organization.

9.2. The basic propositions of the problem of the terminal underreplication.

9.3. Telomeric theory of aging.

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