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Assessment of competence skills

7.2.1. Show and explain the hierarchy of gene regulators.

Lesson number 16

1. Title: Genetics of congenital malformations

2.Aims: To generate in students the knowledge of the role of genetic and teratogenic factors in the occurrence of congenital malformations.

3. Learning objectives:
- To familiarize students with the terms of teratology, teratogenic factors, teratogenic terminatsionnye period, congenital malformations, congenital anomalies and mikroanomalii development, embryology, fetopathy.
- To reveal the role of genetic factors in the formation of congenital malformations,
- To disclose the nature and significance of the critical period of human ontogenesis.
- To reveal the role of the interaction of genetic and environmental factors in the formation of multifactorial congenital malformations.
- To familiarize students with the meaning of congenital malformations in the health of Kazakhstan, their contribution to perinatal and infant mortality.
- To show and prove "the role and importance of a healthy lifestyle in the prevention of congenital malformations.

4. Form of: A Conversation on the topic, filling in the table, the job skills.

5. Tasks related to:
A talk on the following issues:
5.1. Congenital malformations (birth defects): identification and cytogenetic mechanisms of their formation. Malformations, dizrutstsii.
5.2. Classification, diagnosis and prevention of birth defects.
5.3. Critical periods of development.
5.4. Violations of fetal ontogeny (blaetopatii, embryopathy, fetopathy)
5.5. Teratogenic factors, teratogenesis, D hypoid syndrome talidomidpy syndrome. alcohol syndrome. The difference between teratogens and mutagens.
5.6. Protection of public health and promoting a healthy lifestyle (chapter 25. Code of "Nation health and the health care system." 2009)
6. Handout: Test questions.
7. Literature
Summary:
7.1. Genetics. Ed. Ivanov, VI MM. In 2006. a. 291-314.
7.2. IF Zhimulev General and molecular genetics. Novosibirsk. 2006, p. 369-389.
7.3. Medical Biology and Genetics. A textbook for students, ed. Professor.
Kuandykova OU. Almaty, 2004. a. 220-227.
7.4. Kuandykov VU Fundamentals of General and Medical Genetics (a course). Almaty, 2007. a. 63-7l.
7.5. Biology. Ed. Yarygina N. M. Duke. A. In 2001. a. 234-242.
MORE:
7.6. Alikhanian SI.. Akifyev AP. Chernin, LS General genetics of MS. Volume 1. In 1985. a. 344-368.

7.7. Hare R., Butvilovsky VE and other general and medical genetics. R-on-Don., 2002.s. 106-116.
7.8. Issues and Challenges for general biology and general and medical genetics (with explanations). Ed. Professor. Itkesa A. MM. In 2004. with, 68-83.
7.9. SG Inge-Vechtomov Genetics of the basics of breeding. M., 1989. a. 409-429.
7.10. Korochkin L. Introduction to the genetics of development. M., 1999. a. 252.
7.11. Nurtazin ST., Vsevolod E and B. Biology of individual development. A. 2005, p. 260.
7.12. Teratology man. Ed. Lazyuk G. M, 1991. a. 480.
7.13.Meditsinskaya genetics: studies. guide / Robert L.Nyussbaum, Roderick P. Mc Innes.
Huntington F. Willard, trans. from English. A. S. Latynova: ed. NP Bochkov. - Moscow-GEOTAR
Media, 2010, p. 355-363
7.14. Bochkov NP Clinical Genetics, Moscow, 2004, p. 81 - 109.
8. Control:
8.1. Assessment of cognitive kompeteitsii (knowledge)
8.1.1. Quizzes on topics
8.1.2. A test version of the control of -3 to 10 questions
8.2. Assessment of competence skills
8.2.1. Show and explain the nature and significance of the critical period of human ontogenesis.
8.2.2. Show and explain the classification of congenital malformations:
- For reasons
- The prevalence of
- At the time of exposure of teratogenic factors.
8.2.3. Fill in the table: «Differences between the effects of teratogenic and mutagenic agents»

8.3. Evaluation of legal competency.
8,3.1. Protection obsheskhvepnogo health and promoting a healthy lifestyle (25. Codec Republic of Kazakhstan "On the health of the people and the health care system", 2009)
8.4. Assessment skills, self-improvement:

CDS protection on the topic:
7.4.1. Congenital malformations of the cardiovascular system (OM).
7.4.2. Congenital malformations of the facial system: cleft lip and palate (Stom).

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